Take at least 2 of the following:
Will Ferrell
Ben Stiller
Vince Vaughn
Owen Wilson

And you have a ready-made comedy, such as:

Anchorman (2004)
Dodgeball: A True Underdog Story (2004)
Starsky & Hutch (2004)
Old School (2003)
Zoolander (2001)
Meet The Parents (2000)